Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca2+- but not for guanosine 5«-[γ-thio]triphosphate-induced secretion

Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca2+but not for guanosine 5«-[γ-thio]triphosphate-induced secretion Franz MARTIN *, Eva SALINAS†, Jesu! s VAZQUEZ‡ Bernat SORIA* and Juan A. REIG†§ Departments of * Fisiologı!a and †Neuroquı!mica of the Facultad de Medicina and Instituto de Neurociencias, Universidad de Alicante, Ap 374 Alicante 03080, Spain and ‡ Centro de Biologı!a Molecular, Facultad de Ciencias, Universidad Auto! noma, 28049 Madrid, Spain